Keifei Growth Hormone (Mk677) 10mg 60 Capsules

What Is Keifei MK-677?
Keifei MK-677 (chemical name: Ibutamoren Mesylate) is a non-peptide, orally active growth hormone secretagogue. It is frequently categorized alongside SARMs in fitness discussions, but it is not a SARM and not an anabolic steroid. MK-677 acts as a ghrelin mimetic, binding to GHS-R1a receptors in the pituitary and hypothalamus to amplify natural GH secretion.
Each Keifei capsule delivers 10mg of Ibutamoren Mesylate with 60 capsules per bottle. This 10mg dosage is lower than the 25mg/day used in most clinical trials, which some researchers prefer for titrating tolerance, particularly regarding appetite and water retention.

How MK-677 Works: Mechanism of Action
Clinical research from the National Cancer Institute describes Ibutamoren as an “orally bioavailable, small molecule, non-peptide growth hormone secretagogue” that promotes GH release from the pituitary, thereby increasing plasma GH levels.
Unlike exogenous HGH (which suppresses natural production via negative feedback), MK-677 amplifies pulsatile GH secretion—meaning it enhances the body’s own GH pulses rather than replacing them. A 1996 double-blind, placebo-controlled trial in healthy elderly subjects found that MK-677 significantly increased mean 24-hour GH concentration and elevated serum IGF-1 into the normal range for young adults after 2–4 weeks of daily administration.

Potential Benefits (Based on Clinical Literature)
1. Increased Natural Growth Hormone and IGF-1
Research consistently demonstrates dose-dependent elevations in both GH and IGF-1 with oral MK-677 administration. This may support recovery, collagen synthesis, and nitrogen retention.
2. Appetite Stimulation
Increased appetite was among the most commonly reported effects in clinical trials (67% of subjects in one study reported increased appetite vs. 33% on placebo). This may be beneficial for individuals struggling to meet caloric intake goals.
3. Improved Bone Turnover Markers
Short-term MK-677 treatment increased markers of both bone formation and resorption in obese males, suggesting active bone remodeling.
4. Fat-Free Mass Accrual
An 8-week trial in healthy obese males found that fat-free mass increased with MK-677 treatment, though total body fat and visceral fat were unchanged.

Important Safety Warnings & Known Risks
MK-677 has never been approved by any regulatory agency worldwide for human use. Clinical development was effectively discontinued due to safety signals.
Cardiovascular Risk (Congestive Heart Failure Signal):
A clinical trial in elderly hip fracture patients was terminated early after 6.5% of MK-677 patients developed congestive heart failure versus 1.7% on placebo. GH-mediated fluid retention is the suspected mechanism.
Metabolic Risk (Insulin Resistance):
MK-677 increases fasting blood glucose, reduces insulin sensitivity, and raises HbA1c. In one 12-month trial, four subjects required dose reduction due to hyperglycemia.
Potential Cancer Risk (Theoretical):
Sustained IGF-1 elevation is epidemiologically associated with increased risk of breast, prostate, and colorectal cancers. Clinical trials were too small and short to assess this risk adequately.

Common Side Effects:
Increased appetite (very common)
Water retention / edema
Muscle pain / joint pain
Fatigue
Numbness (possible carpal tunnel syndrome)
Elevated prolactin within physiologic range

Egypt-Specific Regulatory Warning
On September 7, 2026, the Egyptian Drug Authority (EDA) issued an official warning listing MK-677 Hormone among unregistered, unknown-source muscle-building preparations. The EDA explicitly warned citizens against using products promoted outside official pharmaceutical channels. Additionally, MK-677 appears on Egypt’s 2024 Prohibited List under Ibutamoren.

Directions for Use (Research Context Only)
Standard research protocols referenced in clinical literature use dosages ranging from 5mg to 25mg once daily:
2mg, 10mg, and 25mg have all been studied
25mg/day was the most common trial dosage
Keifei capsules are 10mg each — research protocols may use 1–2 capsules daily depending on objectives

Timing: Morning administration is often preferred to align with natural GH pulses, though clinical trials used once-daily dosing at various times.
Cycle Considerations (Hypothetical Research Context):
Most clinical studies ran 2 weeks to 12 months
Tolerance to appetite-stimulating effects may develop over 2–8 weeks
No standardized cycling protocol exists for non-medical use

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